Low Ambient Temperature and Intracerebral Hemorrhage: The INTERACT2 Study
Identifieur interne : 001B71 ( Main/Exploration ); précédent : 001B70; suivant : 001B72Low Ambient Temperature and Intracerebral Hemorrhage: The INTERACT2 Study
Auteurs : Danni Zheng [Australie] ; Hisatomi Arima [Australie, Japon] ; Shoichiro Sato [Australie] ; Antonio Gasparrini [Royaume-Uni] ; Emma Heeley [Australie] ; Candice Delcourt [Australie] ; Serigne Lo [Australie] ; Yining Huang [République populaire de Chine] ; Jiguang Wang [République populaire de Chine] ; Christian Stapf [France, Canada] ; Thompson Robinson [Royaume-Uni] ; Pablo Lavados [Chili] ; John Chalmers [Australie] ; Craig S. Anderson [Australie]Source :
- PLoS ONE [ 1932-6203 ] ; 2016.
Descripteurs français
- KwdFr :
- MESH :
- effets indésirables : Basse température.
- physiologie : Pression sanguine.
- étiologie : Hémorragie cérébrale.
- Adulte d'âge moyen, Facteurs de risque, Femelle, Humains, Mâle, Sujet âgé.
English descriptors
- KwdEn :
- MESH :
- adverse effects : Cold Temperature.
- etiology : Cerebral Hemorrhage.
- physiology : Blood Pressure.
- Aged, Female, Humans, Male, Middle Aged, Risk Factors.
Abstract
Rates of acute intracerebral hemorrhage (ICH) increase in winter months but the magnitude of risk is unknown. We aimed to quantify the association of ambient temperature with the risk of ICH in the Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT2) participants on an hourly timescale.
INTERACT2 was an international, open, blinded endpoint, randomized controlled trial of patients with spontaneous ICH (<6h of onset) and elevated systolic blood pressure (SBP, 150–220 mmHg) assigned to intensive (target SBP <140 mmHg) or guideline-recommended (SBP <180 mmHg) BP treatment. We linked individual level hourly temperature to baseline data of 1997 participants, and performed case-crossover analyses using a distributed lag non-linear model with 24h lag period to assess the association of ambient temperature and risk of ICH. Results were presented as overall cumulative odds ratios (ORs) and 95% CI.
Low ambient temperature (≤10°C) was associated with increased risks of ICH: overall cumulative OR was 1.37 (0.99–1.91) for 10°C, 1.92 (1.31–2.81) for 0°C, 3.13 (1.89–5.19) for -10°C, and 5.76 (2.30–14.42) for -20°C, as compared with a reference temperature of 20°C.There was no clear relation of low temperature beyond three hours after exposure. Results were consistent in sensitivity analyses.
Exposure to low ambient temperature within several hours increases the risk of ICH.
ClinicalTrials.gov
Url:
DOI: 10.1371/journal.pone.0149040
PubMed: 26859491
PubMed Central: 4747478
Affiliations:
- Australie, Canada, Chili, France, Japon, Royaume-Uni, République populaire de Chine
- Angleterre, Grand Londres, Nouvelle-Galles du Sud, Île-de-France
- Londres, Paris, Pékin, Sydney
- Université de Sydney
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Le document en format XML
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Hemorrhage: The INTERACT2 Study</title><author><name sortKey="Zheng, Danni" sort="Zheng, Danni" uniqKey="Zheng D" first="Danni" last="Zheng">Danni Zheng</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Division of Neurology and Mental health, The George Institute for Global Health, Sydney, New South Wales, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Division of Neurology and Mental health, The George Institute for Global Health, Sydney, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="aff002"><addr-line>Sydney Medical School, the University of Sydney, Sydney, New South Wales, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Sydney Medical School, the University of Sydney, Sydney, New South Wales</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Arima, Hisatomi" sort="Arima, Hisatomi" uniqKey="Arima H" first="Hisatomi" last="Arima">Hisatomi Arima</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Division of Neurology and Mental health, The George Institute for Global Health, Sydney, New South Wales, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Division of Neurology and Mental health, The George Institute for Global Health, Sydney, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="aff002"><addr-line>Sydney Medical School, the University of Sydney, Sydney, New South Wales, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Sydney Medical School, the University of Sydney, Sydney, New South Wales</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Centre for Epidemiologic Research in Asia, Shiga University of Medical Sciences, Shiga University, Shiga, Japan</addr-line></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Centre for Epidemiologic Research in Asia, Shiga University of Medical Sciences, Shiga University, Shiga</wicri:regionArea><wicri:noRegion>Shiga</wicri:noRegion></affiliation></author><author><name sortKey="Sato, Shoichiro" sort="Sato, Shoichiro" uniqKey="Sato S" first="Shoichiro" last="Sato">Shoichiro Sato</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Division of Neurology and Mental health, The George Institute for Global Health, Sydney, New South Wales, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Division of Neurology and Mental health, The George Institute for Global Health, Sydney, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Gasparrini, Antonio" sort="Gasparrini, Antonio" uniqKey="Gasparrini A" first="Antonio" last="Gasparrini">Antonio Gasparrini</name><affiliation wicri:level="3"><nlm:aff id="aff004"><addr-line>Department of Social and Environmental Health Research, London School of Hygiene & Tropical Medicine, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Social and Environmental Health Research, London School of Hygiene & Tropical Medicine, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Heeley, Emma" sort="Heeley, Emma" uniqKey="Heeley E" first="Emma" last="Heeley">Emma Heeley</name><affiliation wicri:level="4"><nlm:aff id="aff002"><addr-line>Sydney Medical School, the University of Sydney, Sydney, New South Wales, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Sydney Medical School, the University of Sydney, Sydney, New South Wales</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Delcourt, Candice" sort="Delcourt, Candice" uniqKey="Delcourt C" first="Candice" last="Delcourt">Candice Delcourt</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Division of Neurology and Mental health, The George Institute for Global Health, Sydney, New South Wales, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Division of Neurology and Mental health, The George Institute for Global Health, Sydney, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="aff002"><addr-line>Sydney Medical School, the University of Sydney, Sydney, New South Wales, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Sydney Medical School, the University of Sydney, Sydney, New South Wales</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff005"><addr-line>Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Royal Prince Alfred Hospital, Camperdown, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Lo, Serigne" sort="Lo, Serigne" uniqKey="Lo S" first="Serigne" last="Lo">Serigne Lo</name><affiliation wicri:level="4"><nlm:aff id="aff002"><addr-line>Sydney Medical School, the University of Sydney, Sydney, New South Wales, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Sydney Medical School, the University of Sydney, Sydney, New South Wales</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Huang, Yining" sort="Huang, Yining" uniqKey="Huang Y" first="Yining" last="Huang">Yining Huang</name><affiliation wicri:level="3"><nlm:aff id="aff006"><addr-line>Department of Neurology, Peking University First Hospital, Beijing, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Neurology, Peking University First Hospital, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Wang, Jiguang" sort="Wang, Jiguang" uniqKey="Wang J" first="Jiguang" last="Wang">Jiguang Wang</name><affiliation wicri:level="1"><nlm:aff id="aff007"><addr-line>Centre for Epidemiological Studies and Clinical Trials, The Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Centre for Epidemiological Studies and Clinical Trials, The Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Stapf, Christian" sort="Stapf, Christian" uniqKey="Stapf C" first="Christian" last="Stapf">Christian Stapf</name><affiliation wicri:level="3"><nlm:aff id="aff008"><addr-line>Department of Neurology, APHP–Hôpital Lariboisière, DHU NeuroVasc Paris–Sorbonne, Université Paris Diderot–Sorbonne Paris Cité, Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology, APHP–Hôpital Lariboisière, DHU NeuroVasc Paris–Sorbonne, Université Paris Diderot–Sorbonne Paris Cité, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff009"><addr-line>Department of Neuroscience, CRCHUM, University of Montreal, Montreal, Quebec, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Neuroscience, CRCHUM, University of Montreal, Montreal, Quebec</wicri:regionArea><wicri:noRegion>Quebec</wicri:noRegion></affiliation></author><author><name sortKey="Robinson, Thompson" sort="Robinson, Thompson" uniqKey="Robinson T" first="Thompson" last="Robinson">Thompson Robinson</name><affiliation wicri:level="1"><nlm:aff id="aff010"><addr-line>Department of Cardiovascular Sciences and NIHR Biomedical Research Unit in Cardiovascular Disease, University of Leicester, Leicester, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Cardiovascular Sciences and NIHR Biomedical Research Unit in Cardiovascular Disease, University of Leicester, Leicester</wicri:regionArea><wicri:noRegion>Leicester</wicri:noRegion></affiliation></author><author><name sortKey="Lavados, Pablo" sort="Lavados, Pablo" uniqKey="Lavados P" first="Pablo" last="Lavados">Pablo Lavados</name><affiliation wicri:level="1"><nlm:aff id="aff011"><addr-line>Vascular Neurology Program, Neurology Services, Department of Internal Medicine, Clínica Alemana de Santiago, Universidad del Desarrollo, Santiago, Chile</addr-line></nlm:aff><country xml:lang="fr">Chili</country><wicri:regionArea>Vascular Neurology Program, Neurology Services, Department of Internal Medicine, Clínica Alemana de Santiago, Universidad del Desarrollo, Santiago</wicri:regionArea><wicri:noRegion>Santiago</wicri:noRegion></affiliation></author><author><name sortKey="Chalmers, John" sort="Chalmers, John" uniqKey="Chalmers J" first="John" last="Chalmers">John Chalmers</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Division of Neurology and Mental health, The George Institute for Global Health, Sydney, New South Wales, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Division of Neurology and Mental health, The George Institute for Global Health, Sydney, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author><author><name sortKey="Anderson, Craig S" sort="Anderson, Craig S" uniqKey="Anderson C" first="Craig S." last="Anderson">Craig S. Anderson</name><affiliation wicri:level="1"><nlm:aff id="aff001"><addr-line>Division of Neurology and Mental health, The George Institute for Global Health, Sydney, New South Wales, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Division of Neurology and Mental health, The George Institute for Global Health, Sydney, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation><affiliation wicri:level="4"><nlm:aff id="aff002"><addr-line>Sydney Medical School, the University of Sydney, Sydney, New South Wales, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Sydney Medical School, the University of Sydney, Sydney, New South Wales</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="aff005"><addr-line>Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia</addr-line></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Royal Prince Alfred Hospital, Camperdown, New South Wales</wicri:regionArea><wicri:noRegion>New South Wales</wicri:noRegion></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Blood Pressure (physiology)</term><term>Cerebral Hemorrhage (etiology)</term><term>Cold Temperature (adverse effects)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Risk Factors</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Basse température (effets indésirables)</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Hémorragie cérébrale (étiologie)</term><term>Mâle</term><term>Pression sanguine (physiologie)</term><term>Sujet âgé</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Cold Temperature</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Basse température</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cerebral Hemorrhage</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Pression sanguine</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Blood Pressure</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Hémorragie cérébrale</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Risk Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Sujet âgé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="sec001"><title>Background</title><p>Rates of acute intracerebral hemorrhage (ICH) increase in winter months but the magnitude of risk is unknown. We aimed to quantify the association of ambient temperature with the risk of ICH in the Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT2) participants on an hourly timescale.</p></sec><sec id="sec002"><title>Methods</title><p>INTERACT2 was an international, open, blinded endpoint, randomized controlled trial of patients with spontaneous ICH (<6h of onset) and elevated systolic blood pressure (SBP, 150–220 mmHg) assigned to intensive (target SBP <140 mmHg) or guideline-recommended (SBP <180 mmHg) BP treatment. We linked individual level hourly temperature to baseline data of 1997 participants, and performed case-crossover analyses using a distributed lag non-linear model with 24h lag period to assess the association of ambient temperature and risk of ICH. Results were presented as overall cumulative odds ratios (ORs) and 95% CI.</p></sec><sec id="sec003"><title>Results</title><p>Low ambient temperature (≤10°C) was associated with increased risks of ICH: overall cumulative OR was 1.37 (0.99–1.91) for 10°C, 1.92 (1.31–2.81) for 0°C, 3.13 (1.89–5.19) for -10°C, and 5.76 (2.30–14.42) for -20°C, as compared with a reference temperature of 20°C.There was no clear relation of low temperature beyond three hours after exposure. Results were consistent in sensitivity analyses.</p></sec><sec id="sec004"><title>Conclusions</title><p>Exposure to low ambient temperature within several hours increases the risk of ICH.</p></sec><sec id="sec005"><title>Trial Registration</title><p>ClinicalTrials.gov <ext-link ext-link-type="uri" xlink:href="https://clinicaltrials.gov/ct2/show/NCT00716079">NCT00716079</ext-link></p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Krishnamurthi, Rv" uniqKey="Krishnamurthi R">RV Krishnamurthi</name></author><author><name sortKey="Feigin, Vl" uniqKey="Feigin V">VL Feigin</name></author><author><name sortKey="Forouzanfar, Mh" uniqKey="Forouzanfar M">MH Forouzanfar</name></author><author><name sortKey="Mensah, Ga" uniqKey="Mensah G">GA Mensah</name></author><author><name sortKey="Connor, M" uniqKey="Connor M">M Connor</name></author><author><name sortKey="Bennett, Da" uniqKey="Bennett D">DA 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Sud</li><li>Île-de-France</li></region><settlement><li>Londres</li><li>Paris</li><li>Pékin</li><li>Sydney</li></settlement><orgName><li>Université de Sydney</li></orgName></list><tree><country name="Australie"><noRegion><name sortKey="Zheng, Danni" sort="Zheng, Danni" uniqKey="Zheng D" first="Danni" last="Zheng">Danni Zheng</name></noRegion><name sortKey="Anderson, Craig S" sort="Anderson, Craig S" uniqKey="Anderson C" first="Craig S." last="Anderson">Craig S. Anderson</name><name sortKey="Anderson, Craig S" sort="Anderson, Craig S" uniqKey="Anderson C" first="Craig S." last="Anderson">Craig S. Anderson</name><name sortKey="Anderson, Craig S" sort="Anderson, Craig S" uniqKey="Anderson C" first="Craig S." last="Anderson">Craig S. Anderson</name><name sortKey="Arima, Hisatomi" sort="Arima, Hisatomi" uniqKey="Arima H" first="Hisatomi" last="Arima">Hisatomi Arima</name><name sortKey="Arima, Hisatomi" sort="Arima, Hisatomi" uniqKey="Arima H" first="Hisatomi" last="Arima">Hisatomi Arima</name><name sortKey="Chalmers, John" sort="Chalmers, John" uniqKey="Chalmers J" first="John" last="Chalmers">John Chalmers</name><name sortKey="Delcourt, Candice" sort="Delcourt, Candice" uniqKey="Delcourt C" first="Candice" last="Delcourt">Candice Delcourt</name><name sortKey="Delcourt, Candice" sort="Delcourt, Candice" uniqKey="Delcourt C" first="Candice" last="Delcourt">Candice Delcourt</name><name sortKey="Delcourt, Candice" sort="Delcourt, Candice" uniqKey="Delcourt C" first="Candice" last="Delcourt">Candice Delcourt</name><name sortKey="Heeley, Emma" sort="Heeley, Emma" uniqKey="Heeley E" first="Emma" last="Heeley">Emma Heeley</name><name sortKey="Lo, Serigne" sort="Lo, Serigne" uniqKey="Lo S" first="Serigne" last="Lo">Serigne Lo</name><name sortKey="Sato, Shoichiro" sort="Sato, Shoichiro" uniqKey="Sato S" first="Shoichiro" last="Sato">Shoichiro Sato</name><name sortKey="Zheng, Danni" sort="Zheng, Danni" uniqKey="Zheng D" first="Danni" last="Zheng">Danni Zheng</name></country><country name="Japon"><noRegion><name sortKey="Arima, Hisatomi" sort="Arima, Hisatomi" uniqKey="Arima H" first="Hisatomi" last="Arima">Hisatomi Arima</name></noRegion></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Gasparrini, Antonio" sort="Gasparrini, Antonio" uniqKey="Gasparrini A" first="Antonio" last="Gasparrini">Antonio Gasparrini</name></region><name sortKey="Robinson, Thompson" sort="Robinson, Thompson" uniqKey="Robinson T" first="Thompson" last="Robinson">Thompson Robinson</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Huang, Yining" sort="Huang, Yining" uniqKey="Huang Y" first="Yining" last="Huang">Yining Huang</name></noRegion><name sortKey="Wang, Jiguang" sort="Wang, Jiguang" uniqKey="Wang J" first="Jiguang" last="Wang">Jiguang Wang</name></country><country name="France"><region name="Île-de-France"><name sortKey="Stapf, Christian" sort="Stapf, Christian" uniqKey="Stapf C" first="Christian" last="Stapf">Christian Stapf</name></region></country><country name="Canada"><noRegion><name sortKey="Stapf, Christian" sort="Stapf, Christian" uniqKey="Stapf C" first="Christian" last="Stapf">Christian Stapf</name></noRegion></country><country name="Chili"><noRegion><name sortKey="Lavados, Pablo" sort="Lavados, Pablo" uniqKey="Lavados P" first="Pablo" last="Lavados">Pablo Lavados</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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